韩晓娟博士
来源:基转所 作者:基础与转化医学研究所管理员 点击数: 发表时间:2019-04-17 14:33:33

    

  韩晓娟,女,讲师,理学博士。2018年毕业于四川大学生物治疗国家重点实验室,获细胞生物学博士学位。目前从事衰老与神经退行性疾病的细胞分子机制研究,专长细胞生物学、分子生物学、衰老与自噬相关领域的理论和实验技术。作为主研人员参与和完成了多个国家科技部和国家自然科学基金项目,涉及能量代谢,自噬和炎症对衰老及衰老相关疾病影响的机制研究。已发表SCI论文9篇,其中第一作者论文2篇。

  研究方向:                                           衰老的细胞分子机制

   衰老与神经退行性疾病

  发表论文:                                        

  1,Han X, Tai H, Wang X, Wang Z, Zhou J, Wei X, Ding Y, Gong H, Mo C, Zhang J, Qin J, Ma Y, Huang N, Xiang R, Xiao H. AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD (+) elevation.Aging Cell.2016 Jun; 15(3):416-27.(IF=7.6)

  2,Han X*, Chen H*, Zhou J, Gong H, Tai H, Wang X, Huang N, Fang T, Qin J, Wang F, Xiao H.The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration.J Cell Physiol. 2018 May; 233(5):3945-3954.(IF=3.9)

  3,Tai H*, Wang Z*, Gong H*,Han X, Zhou J, Wang X, Wei X, Ding Y, Huang N, Qin J, Zhang J, Wang S, Gao F, Chrzanowska-Lightowlers ZF, Xiang R, Xiao H. Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence.Autophagy. 2017 Jan 2; 13(1):99-113.(IF=11.1)

  4,Tai H*, Wang X*, Zhou J*, Han X, Fang T, Gong H, Huang N, Chen H, Qin J, Yang M, Wei X, Yang L, Xiao H. Protein kinase Cβ activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation.FASEB J. 2017 Oct; 31(10):4396-4406.(IF=5.6)

  5,Mo C, Yang M,Han X, Li J, Wei D, Tai H, Ding Y, Zhang J, Qin J, Xiao H.Fat mass and obesity-associated protein attenuates lipid accumulation in macrophage foam cells and alleviates atherosclerosis in apolipoprotein E-deficient mice.Journal of Hypertension.2017 Apr; 35(4):810-821.(IF=4.1)

  6,Wang X*, Huang N*, Yang M, Wei D, Tai H, Han X, Gong H, Zhou J, Qin J, Wei X, Chen H, Fang T, Xiao H. FTO is required for myogenesis by regulating mTOR-PGC-1α pathway-mediated mitochondria biogenesis.Cell Death Dis. 2017 Mar 23; 8(3): e2702. (IF=5.6)

  7,Wang L*, Wei D*,Han X, Zhang W, Fan C, Zhang J, Mo C, Yang M, Li J, Wang Z, Zhou Q, Xiao H. The combinational effect of vincristine and berberine on growth inhibition and apoptosis induction in hepatoma cells.J Cell Biochem. 2014 Apr; 115(4):721-30.(IF=2.9)

  8,Mo C, Wang L, Zhang J, Numazawa S, Tang H, Tang X,Han X, Li J, Yang M, Wang Z, Wei D, Xiao H. The Crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice.Antioxid Redox Signal. 2014 Feb; 1; 20(4);574-88.(IF=6.5)

  9,Yang M, Wei D, Mo C, Zhang J, Wang X,Han X, Wang Z, Xiao H. Saturated fatty acid palmitate-induced insulin resistance is accompanied with myotube loss and the impaired expression of health benefit myokine genes in C2C12 myotubes.Lipids Health Dis. 2013 Jul; 18; 12:104.(IF=2.7)

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