李科博士
来源:基转所 作者:基础与转化医学研究所管理员 点击数: 发表时间:2019-04-17 14:44:18



 李科,男,西安医学院基础与转化医学研究所讲师。2016年9月毕业于西安交通大学,获博士学位。研究方向为用于诊疗的多功能纳米载体。现任中国微循环学会转化医学专业委员会青年委员,2014-2016年赴美国堪萨斯大学交流一年。在发表学术论文10余篇。申请发明专利8项。

  主持科研项目

   国家自然科学基金项目1项,

   陕西省教育厅重点项目1项。

  发表论文

  1.Ke Li,Hao Liu, Wei Gao, Mu Chen, Yun Zeng, Jiajun Liu, Liang Xu*and Daocheng Wu*. Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy.Biomaterials,2015, 39, 131-144.

  2.Hanrui Li#,Ke Li#, Yunpeng Dai, Xinyi Xu, Xu Cao, Qi Zeng, Huyulong He, Liaojun Pang, Jimin Liang, Xueli Chen, Yonghua Zhan*. In vivo near infrared fluorescence imaging and dynamic quantification of pancreatic metastatic tumors using folic acid conjugated biodegradable mesoporous silica nanoparticles.Nanomed-Nanotechnol, 2018, 14, 1867-1877.

  3.Xiaoying Lei#,Ke Li#, Yan Liu#, Zhenyu Wang, Banjun Ruan, Li Wang, An Xiang, Daocheng Wu*, Zifan Lu*. Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and α-tocopheryl succinate enhance anti-tumor effect in vivo. Int J Nanomed, 2017, 12, 5701-5715. 

  4.Ya Wang, Youshen Wu,Ke Li, Shihong Shen, Zeying Liu, and Daocheng Wu*. Ultralong Circulating Lollipop-Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy.Adv Funct Mater,2018, 1805582.

  5.Shihong Shen, Youshen Wu,Ke Li, Ya Wang Jimin Wu Yun Zeng, Daocheng Wu*. Versatile hyaluornic acid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles: Mulitiple tumor targeting,highle efficient synergistic chemotherapy and real-time self-montoring.Biomaterials, 2018,154,197-212.

  6.Peng Tang, Yongchun Liu, Yiming Liu, Hongru Meng, Zeying Liu,Ke Li, Daocheng Wu∗, Thermochromism-induced temperature self-regulation and alternating photothermal nanohelix clusters for synergistic tumor chemo/photothermal therapy.Biomaterials, 2019, 88, 12-23.

  7.Jiajun Liu, Youshen Wu, Yao Yu,Ke Li, Yuanyuan Ji, Daocheng Wu *. Quantitative ratiometric phosphorescence hypoxia–sensing nanoprobes based on Quantum Dots/Ir(III) glycerol monoolein cubic-phase nanoparticles.   Biosensors and Bioelectronics, 2017, 98, 119-125.

  8.Youshen Wu, Liu Jiajun, Ya Wang,Ke Li, Jianhua Xu, Daocheng Wu*. Novel ratiomatric flourescence nanothermometers based on flouropores-labeled short single-stranded DNA. ACS Appl Mater Inter, 2017, 9, 11073-11081.

  9.Wei Gao, Yongchun Liu, Guixia Jing, Ke Li, Yuan Zhao, Baoyong Sha, Qiang Wang*, Daocheng Wu*. Rapid and efficient crossing blood-brain barrier: Hydrophobic drug delivery system based on propionylated amylose helix nanoclusters.Biomaterials, 2017,113,133-144.

  10.Hao Liu,Ke Li, Lan Lan, Jingwen Ma, Yun Zeng, Liang Xu*and Daocheng Wu*. Double-layered hyaluronic acid/stearic acid modified polyethyleneimine nanoparticles encapsulating (-)-gossypol: a nanocarrier for chiral anticancer drugs.J. Mater. Chem. B, 2014, 2, 5238-5248.

  11.Hao Liu,Ke Li, Liang Xu, Daocheng Wu*.Bilayered near-infrared fluorescent nanoparticlesbased on low molecular weight PEI for tumor-targetedin vivo imaging.J Nanopart Res, 2014, 16, 2784. 

  12.Jingjing Sun, Yichao Chen,Ke Li, Yixian Huang, Xiaolan Zhang, Wenchen Zhao, Yuan Wei, Liang Xu, Raman Venkataramanan and Song Li*.A prodrug micellar carrier assembled from polymers with pendant farnesyl thiosalicylic acid moieties for improved delivery of paclitaxel.Acta Biomaterialia,2016, 43, 282-291.

  13.Xiaoqing Wu, Wenhua Tang, Rebecca T. Marquez,Ke Li, Chad A. Highfill, Fengtian He, Jiqing Lian, Jiayuh Lin, James R. Fuchs, Min Ji, Ling Li, Liang Xu*. Overcoming chemo/radio-resistance of pancreatic cancer by inhibiting STAT3 signaling.Oncotarget, 2016, 10, 11708-11723.

  申请专利

  1.李科,徐仓宝,陈玉龙,张亚萍,杨颖,贾敏,岳波.一种用于冠状动脉痉挛治疗的纳米制剂及其制备方法. CN 107625745 A

  2.吴道澄,李科,刘佳俊,刘浩,曾鋆.自组装法制备棉酚及其衍生物普郎尼克纳米粒子的方法. CN 104523606 B

  3.张瑞三,李科,成凡,邵玲巧,徐仓宝,汪洋.一种ABT-199纳米乳分散剂及其制备方法. CN 108042498 A

  4.李雪萍,李科,徐仓宝,周韵,杨颖,周连锁,岳波.一种阿霉素与ABT-263双药纳米载体及其制备方法.  CN 108159022 A

  5.李雪萍,周韵,李科,徐仓宝王惠民,周连锁,闫梦茹.一种ABT-199与盐酸阿霉素联合纳米制剂其制备方法. CN 107898798 A

  6.陈玉龙,徐仓宝,李科,张亚萍,贾敏,杨颖,刘欢欢. 一种用于2型糖尿病治疗的纳米制剂及其制备方法.CN107468670A

  7.陈玉龙,刘欢欢,李科,张寒,贾敏,徐仓宝.一种薰衣草油羟丙基‑β‑环糊精包合物的制备方法. CN107496938A

  8.顾雪凡,陈刚,李科,马新培,尤丽丝·买买提.油田用示踪剂的荧光素衍生物制备方法与应用. CN 103554126 B



Copyright©2010-2013  jzs.xiyi.edu.cn  联系电话:029-86177465  传真:029-86177466

地址:西安市未央区辛王路1号西安医学院基础与转化医学研究所 邮编:710021