苟兴春教授
来源:基转所 作者:基础与转化医学研究所管理员 点击数: 发表时间:2019-04-17 14:52:52



  苟兴春,博士,博士后、教授、耶鲁大学访问学者;基础与转化医学研究所所长陕西省中青年科技创新领军人才、全国优秀创新创业导师、西安医学院领军人才;2010年获JCA“青年科学家奖”(Young Scientist Award)。

  学术任职:

  科技部国际合作重点项目评审专家、中国细胞生物学学会第十届理事、细胞工程与转基因生物分会委员、陕西省细胞生物学学会常务理事、中国药理学会麻醉分会委员、陕西省肿瘤标志委员会委员、转化医学电子杂志编委、中国老年医学学会基础与转化医学分会青年委员、Cancer Translational Medicine编委会成员、10余家国际期刊评审专家、国家自然科学基金通讯评审专家、广东省科技咨询专家库成员。  

  生物学学士、神经生物学硕士(师从鞠躬院士)、细胞生物学博士(师从陈志南院士)、麻醉学博士后、耶鲁大学神经外科访问学者。专长于神经再生与脑保护、阿尔茨海默病的机制与防治。

  教育、工作经历:

  1992-1996年,兰州大学生命科学学院;

  1996-2003年,西安迪赛生物药业,工程师;

  2003年就读第四军医大学神经生物学硕士研究生,在导师鞠躬院士指导下,从事中枢神经再生的研究,2006年7月获硕士学位;

  2006年9月就读第四军医大学细胞生物学专业,攻读博士学位,导师为陈志南院士,从事自噬与肿瘤的相关研究。

  2009年-至今,在西安医学院细胞生物学教研室任教与科研;

  2011年-2013年,第四军医大学麻醉学专业博士后;

  2013.12-2015.01,耶鲁大学神经外科访问学者。

  国家级项目(主持):

  1、2014年国家自然科学基金面上项目,70万。(81471415)  "Aβ-PirB-Tau"通路调控突触可塑性:阿尔茨海默症发生的分子机制及防治策略探讨。

  2、2010年国家自然科学基金面上项目,30万。(81071060)PirB重链VHH抗体的筛选及其治疗脑缺血损伤的研究。

  3、2012年国家自然科学基金面上项目,70万。(81271290)靶向运载Ngn2诱导星形胶质细胞转分化为神经元:促进缺血性脑损伤后神经功能恢复的新策略。

  4、2016人社部留学人员择优资质项目,Aβ-PirB-Tau通路参与AD疾病的分子机制研究,8万。

  厅局级课题2项(略)

  发表的部分文章:

  1.Xi Yu,Xingchun Gou(并列第一), Peng Wu, Liang Han, Daofeng Tian, Fengyi Du, Zeming Chen, Fuyao Liu, Gang Deng, Ann Chen, Chao Ma, Jun Liu, Sara M. Hashmi, Xing Guo, Xiaolong Wang, Haitian Zhao, Xinran Liu, Xudong Zhu, Kevin Sheth, Qianxue Chen, Louzhen Fan, Jiangbing Zhou*.Activatable Protein Nanoparticles for Targeted Delivery of Therapeutic Peptides.Advance Material,(IF21.95)

  2.Mi YJ, Chen H1, Guo N, Sun MY, Zhao ZH, Gao XC, Wang XL, Zhang RS, Zhou JB,Gou XC(通讯作者)..Inhibition of PirB Activity by TAT-PEP Improves Mouse Motor Ability and Cognitive BehaviorFront Aging Neurosci. 2017 Jun 20;9:199. doi: 10.3389/fnagi.2017.00199. eCollection 2017. (IF4.504)

  3.Zhao, Z.H., B. Deng, H. Xu, J.F. Zhang, Y.J. Mi, X.Z. Meng,X.C. Gou(通讯作者), and L.X. Xu, PirB Overexpression Exacerbates Neuronal Apoptosis by Inhibiting TrkB and mTOR Phosphorylation After Oxygen and Glucose Deprivation Injury.Cell Mol Neurobiol, 2017. 37(4): p. 707-715. (IF2.939)

  4.Zhao, W., H. Qian, R. Zhang, X. Gao, andX. Gou(通讯作者), MicroRNA targeting microtubule cross-linked protein (MACF1) would suppress the invasion and metastasis of malignant tumor.Med Hypotheses, 2017. 104: p. 25-29. (IF1.45)

  5.Gao, X., Y. Mi, N. Guo, H. Xu, L. Xu,X. Gou(通讯作者), and W. Jin, Cytokine-Induced Killer Cells As Pharmacological Tools for Cancer Immunotherapy.Front Immunol, 2017. 8: p. 774. (IF6.428)

  6.Gou, X., X. Tang, D.K. Kong, X. He, X. Gao, N. Guo, Z. Hu, Z. Zhao, and Y. Chen, CD147 is increased in HCC cells under starvation and reduces cell death through upregulating p-mTOR in vitro.Apoptosis, 2015(第一作者)(IF1.45).

  7.Deng B, Li Y,Gou X(共同第一作者),et.al,TAT-PEP enhanced neurobehavioral functional recovery by facilitating axonal regeneration and corticospinal tract projection after stroke.Mol Neurobiol. 2016 Dec 16. [Epub ahead of print](IF6.190)

  8.Gao X,Mi Y,Guo N,Hu Z,Hu F,Liu D,Gao L,Gou X(通讯作者),Jin W.Disrupted in schizophrenia 1 (DISC1) inhibits glioblastoma development by regulating mitochondria dynamics. Oncotarget.online. PMID: 27852062 DOI: 10.18632/oncotarget.13290(IF5.1651)

  9.Gou, X.C., D. Kong, and X. Tang, Contradictory Relationships between Cancer and Normal Cells and Implications for Anti-cancer Therapy.Asian Pac J Cancer Prev, 2015. 16(13): p. 5143-7.(第一作者)

  10.Gou, Z., Y. Mi, F. Jiang, B. Deng, J. Yang, andX. Gou, PirB is a novel potential therapeutic target for enhancing axonal regeneration and synaptic plasticity following CNS injury in mammals.J Drug Target, 2014. 22(5): p. 365-71.(IF=2.723,通讯作者)

  11.Gou, X., Q. Zhang, N. Xu, B. Deng, H. Wang, L. Xu, and Q. Wang, Spatio-temporal expression of paired immunoglobulin-like receptor-B in the adult mouse brain after focal cerebral ischaemia.Brain Inj, 2013. 27(11): p. 1311-5.(IF1.971)

  12.Gao, X., Y. Mi, A. Yan, B. Sha, N. Guo, Z. Hu, N. Zhang, F. Jiang, andX. Gou, The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis.Asia Pac J Clin Oncol, 2014.(通讯作者)

  13.Guo, N., A. Yan, X. Gao, Y. Chen, X. He, Z. Hu, M. Mi, X. Tang, andX. Gou, Berberine sensitizes rapamycinmediated human hepatoma cell death in vitro.Mol Med Rep, 2014. 10(6): p. 3132-8.(通讯作者)

  14.Chen, Y.,X. Gou, X. Ke, H. Cui, and Z. Chen, Human tumor cells induce angiogenesis through positive feedback between CD147 and insulin-like growth factor-I.PLoS One, 2012. 7(7): p. e40965.

  15.Tang, X., N. Guo, L. Xu,X. Gou, and M. Mi, CD147/EMMPRIN: an effective therapeutic target for hepatocellular carcinoma.J Drug Target, 2012.(通讯作者)

  16.Hou, Q., X. Tang, H. Liu, J. Tang, Y. Yang, X. Jing, Q. Xiao, W. Wang,X. Gou, and Z. Wang, Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147.Cancer Sci, 2011. 102(7): p. 1287-92. .(通讯作者)

  17.Deng, B.,X. Gou, H. Chen, L. Li, H. Zhong, H. Xu, F. Jiang, Z. Zhao, Q. Wang, and L. Xu, Targeted delivery of neurogenin-2 protein in the treatment for cerebral ischemia-reperfusion injury.Biomaterials, 2013. 34(34): p. 8786-97.(共同第一)

  18.Chen, Y., X. Gou, D.K. Kong, X. Wang, J. Wang, Z. Chen, C. Huang, and J. Zhou, EMMPRIN regulates tumor growth and metastasis by recruiting bone marrow-derived cells through paracrine signaling of SDF-1 and VEGF.Oncotarget, 2015. 6(32): p. 32575-85.

  19.Gao, X., Y. Mi, A. Yan, B. Sha, N. Guo, Z. Hu, N. Zhang, F. Jiang, and X. Gou, The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis.Asia Pac J Clin Oncol, 2015. 11(4): p. e13-21.

  20.Zhao, Y., B. Deng, Y. Li, L. Zhou, L. Yang,X. Gou, Q. Wang, G. Chen, H. Xu, and L. Xu, Electroacupuncture Pretreatment Attenuates Cerebral Ischemic Injury via Notch Pathway-Mediated Up-Regulation of Hypoxia Inducible Factor-1alpha in Rats.Cell Mol Neurobiol, 2015. 35(8): p. 1093-103.

  21.Gou, X., Q. Wang, Q. Yang, L. Xu, and L. Xiong,TAT-NEP1-40 as a novel therapeutic candidate for axonal regeneration and functional recovery after stroke.J Drug Target, 2011. 19(2): p. 86-95.

  22.Wang, Q.,X. Gou(co-first author), L. Xiong, W. Jin, S. Chen, L. Hou, and L. Xu, Trans-activator of transcription-mediated delivery of NEP1-40 protein into brain has a neuroprotective effect against focal cerebral ischemic injury via inhibition of neuronal apoptosis.Anesthesiology, 2008. 108(6): p. 1071-80.

  23.Chen, Y., H. Zhang,X. Gou, Y. Horikawa, J. Xing, and Z. Chen, Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis.Cancer Lett, 2009. 278(1): p. 113-21.

  24.Gou, X., Q. Ru, H. Zhang, Y. Chen, L. Li, H. Yang, J. Xing, and Z. Chen, HAb18G/CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 down-regulation.Cancer Sci, 2009. 100(5): p. 837-43.(first author)

  25.Wang, Q., Q. Ding, Y. Zhou,X. Gou, L. Hou, S. Chen, Z. Zhu, and L. Xiong, Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits.Anesthesiology, 2009. 110(6): p. 1279-86.

  26.Wang, Q.,X. Gou, W. Jin, L. Xiong, L. Hou, S. Chen, H. Zhang, X. Zhu, and L. Xu, TAT-mediated protein transduction of Nogo extracellular peptide 1-40 and its biological activity.Cell Mol Neurobiol, 2009. 29(1): p. 97-108.(co-first author)

  27.Wang, Q., Y. Peng, S. Chen,X. Gou, B. Hu, J. Du, Y. Lu, and L. Xiong, Pretreatment with electroacupuncture induces rapid tolerance to focal cerebral ischemia through regulation of endocannabinoid system.Stroke, 2009. 40(6): p. 2157-64.

  28.Wang, Q., F. Wang, X. Li, Q. Yang, X. Li, N. Xu, Y. Huang, Q. Zhang,X. Gou, S. Chen, and L. Xiong, Electroacupuncture pretreatment attenuates cerebral ischemic injury through alpha7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats.J Neuroinflammation, 2012. 9: p. 24.

  29.Guo, F., W.L. Jin, L.Y. Li, W.Y. Song, H.W. Wang,X.C. Gou, Y.J. Mi, Q. Wang, and L. Xiong, M9, a novel region of amino-Nogo-A, attenuates cerebral ischemic injury by inhibiting NADPH oxidase-derived superoxide production in mice.CNS Neurosci Ther, 2013. 19(5): p. 319-28.

  30.Sha, B., W. Gao, S. Wang,X. Gou, W. Li, X. Liang, Z. Qu, F. Xu, and T.J. Lu, Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague-Dawley rats.J Appl Toxicol, 2014. 34(4): p. 345-56.

  获奖:

  1.苟兴春,Young Scientist Award(青年科学家奖),Cancer Science(癌症科学杂志),2010

  2.苟兴春,第六届亚太肿瘤学术会议论文二等奖,2008

  3.第一届天士力奖教金获得者

  4.连续3年获西安医学院优秀教师

  专利:申请国家专利4项,获国家发明专利授权3项。

  学生培养:

  1)组织指导大学生参加《全国大学生基础医学创新论坛及实验设计大赛》,获3项三等奖。

  2)指导本科生发表核心期刊论文4篇(其中指导我校大学生首次发表论文1篇,实现大学生发表论文零的突破,发表在《神经解剖杂志》)

  3)指导的研究生获国家优秀奖学金

  4)指导的本科生80%都考取了研究生,本科期间有效的科研训练,是他们在研究生阶段奠定了良好的科研基础。

  5)指导多项本科生承担的“大学生创新创业计划项目”


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